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Se, being a cofactor of GPX which protects body cells from damage by free radicals, is essential for reduction of inflammation and maintenance of the integrity of cell function, while Se deficiency predisposes to inflammation and diminishes the inflammatory response: supplementation effectively attenuates inflammatory activity [40]
The magnitude of response in this system is an integrated composite of the rate of Gs-Venus recruitment and activation (that will release the G protein from the activated receptor)
In that sense, it is one of the strongest confirmatory tests for B12 deficiency
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